The Relationship of Headache with Inflammatory Serum Parameters and Disease Severity in COVID-19 Patients

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Düzce Med J, vol.22, pp.44-50, 2020 (Refereed Journals of Other Institutions) identifier

  • Publication Type: Article / Article
  • Volume: 22
  • Publication Date: 2020
  • Doi Number: 10.18678/dtfd.776731
  • Title of Journal : Düzce Med J
  • Page Numbers: pp.44-50


Aim: Most of the coronavirus disease 2019 (COVID-19) patients have respiratory symptoms; however, various neurological symptoms, such as headache, can be seen. The pathophysiological mechanism of headache in COVID-19 is unknown completely. In our study, we aimed to investigate the relationship between headache and inflammatory markers and disease severity in COVID-19 patients. Material and Methods: Two hundred and three hospitalized patients with a polymerase chain reaction (PCR)-confirmed COVID-19 diagnosis between 15 March and 01 June 2020 were retrospectively investigated. A total of 62 patients with headache symptoms (n=31) and without headache symptoms (n=31), who were age and gender-matched, were included in the study. The demographic characteristics, inflammatory serum parameters, neutrophil/lymphocyte ratio (NLR), C-reactive protein (CRP)/albumin ratio (CAR), hospitalization times, and disease severity were determined. Results: Of the 203 COVID-19 patients, 36 (17.7%) had a headache, and it was the fourth most common symptom. Headache accompanied other symptoms in all patients. Of the patients with headache, 14 (45.2%) were female, 17 (54.8%) were male, and the mean age was 37.74±16.65 years. In our COVID-19 patients, the neutrophil count, NLR, CRP, CAR were significantly higher, and hospital stay was longer in patients with headache than those without headache (p=0.023, p=0.041, p=0.034, p=0,048 and p=0.049, respectively). Conclusion: As a result, the increased inflammatory response may play a role in the pathogenesis of headache in COVID-19 patients. Our study is the first study that evaluated the relationship between headache symptom and inflammation in COVID-19 patients. Further research is needed on this subject. Keywords: COVID-19; headache; neutrophil-lymphocyte ratio; C-reactive protein; albumin.