The effects of low-level laser therapy on polycystic ovarian syndrome in rats: three different dosages


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POLAT B., OKUR D. T., ÇOLAK A., Yilmaz K., ÖZKARACA M., ÇOMAKLI S.

LASERS IN MEDICAL SCIENCE, vol.38, no.1, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.1007/s10103-023-03847-6
  • Journal Name: LASERS IN MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, BIOSIS, Biotechnology Research Abstracts, CINAHL, Communication Abstracts, MEDLINE
  • Keywords: Estradiol valerate, Low-level laser therapy, Polycystic ovary syndrome, Rat
  • Ataturk University Affiliated: Yes

Abstract

The main objective of this in vivo study was to investigate the effect of different low-level laser therapy (LLLT) doses on polycystic ovary syndrome (PCOS). In the present experimental study, a single dosage of estradiol valerate (EV) was administered to induce PCOS in female rats. After administration of the EV for induction of PCOS, rats were divided into 5 groups (n = 8/group): C group (animals that were not exposed to any form of procedure), PC group (no treatment following EV induction), L-1 group (1 J/cm(2) LLLT treatment following EV induction), L-2 group (2 J/cm(2) LLLT treatment following EV induction), L-3 group (6 J/cm(2) LLLT treatment following EV induction). The results indicated that no significant difference was found in the serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and progesterone (P4) between the C and L-2 groups (p < 0.05). Although the serum levels of testosterone (T) were significantly higher in the C group compared with other groups (p < 0.05), the L-2 group was determined to be the closest to the C group. Additionally, the LH, FSH, and T receptor level of the L-2 group was closest to the C group. In conclusion, a 2 J/cm(2) dosage of LLLT (L-2 group) can be considered the most potentially effective treatment of PCOS in the rat. However, more studies are needed to determine the optimal dose of LLLT for the treatment of PCOS.