Morin attenuates acrylamide-induced testicular toxicity in rats by regulating the NF-kappa B, Bax/Bcl-2 and PI3K/Akt/mTOR signaling pathways

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Küçükler S., Caglayan C., Darendelioğlu E., Kandemir F. M.

LIFE SCIENCES, cilt.261, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 261
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.lfs.2020.118301
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Acrylamide, Apoptosis, Inflammation, Morin, Oxidative stress, Testicular toxicity, INDUCED OXIDATIVE STRESS, INDUCED NEUROTOXICITY, CELLS, INFLAMMATION, APOPTOSIS, AUTOPHAGY, PROLIFERATION, TRANSCRIPTION, PROSTATE, EXTRACT
  • Atatürk Üniversitesi Adresli: Evet

Özet

Aim: Acrylamide (AC) is a carcinogenic substance which is formed during the heating of starchy foods at high temperatures and constitutes an important risk for human health. Therefore, reducing the detrimental effects of AC has become an important research topic. This study was performed to evaluate the protective effect of morin against the testicular toxicity induced by AC in male rats.