alpha-LIPOIC ACID AS A POTENTIAL TARGET FOR THE TREATMENT OF LUNG INJURY CAUSED BY CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS MODEL IN RATS


Çadırcı E. , Altunkaynak B. Z. , Halıcı Z. , Odabasoglu F. , Uyanık M. H. , Gundogdu C., ...More

SHOCK, vol.33, no.5, pp.479-484, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.1097/shk.0b013e3181c3cf0e
  • Title of Journal : SHOCK
  • Page Numbers: pp.479-484
  • Keywords: Acute lung injury, alpha-lipoic acid, inflammatory cytokines, NF-kappa B, oxidative stress, sepsis, NF-KAPPA-B, RESPIRATORY-DISTRESS SYNDROME, HEMORRHAGIC-SHOCK, ACTIVATION, ACETYLCYSTEINE, TRANSCRIPTION, INFLAMMATION, DYSFUNCTION, EXPRESSION, RELEASE

Abstract

One of the common lethal complications of septic shock, a major cause of morbidity and mortality in patients with severe trauma and so on, is acute lung injury. alpha-Lipoic acid (ALA), with antioxidant properties, is a popular agent. Thus, we investigated the potential protective effects of ALA (200 mg/kg) on sepsis-induced acute lung injury. Rats were exposed to cecal ligation and puncture (CLP) to induce sepsis. Rat groups were designed as (a) sham operated, (b) sham operated + ALA treated, (c) CLP applied, (d) CLP + ALA treated. Sixteen hours after CLP induction, serum samples and lung tissues were obtained for biochemical and histopathological examination. alpha-Lipoic acid decreased the serum levels of inflammatory cytokines such as TNF-alpha and IL-6, which increased after CLP. Increased activity of nuclear factor. B in septic lung tissues was decreased by ALA. alpha-Lipoic acid improved the decreased antioxidant activity and alleviated the increased oxidant activity, which occurred after CLP application. We can suggest that ALA showed beneficial effects by decreasing nuclear factor. B activation in lung tissues, resulting in decreased serum levels of TNF-alpha and IL-6, and also increasing the antioxidant capacity of the lungs.