Effects of Polygonum cognatum Meissn. extract on indomethacin induced gastric damage in rats

BAYIR Y., Tagiyeva N., ALBAYRAK A., Ismayilov A., AKPINAR E., TOKTAY E., ...More

BIOTECHNIC & HISTOCHEMISTRY, vol.98, no.6, pp.424-431, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 98 Issue: 6
  • Publication Date: 2023
  • Doi Number: 10.1080/10520295.2023.2221040
  • Journal Name: BIOTECHNIC & HISTOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.424-431
  • Keywords: Antioxidants, phytotherapy, Polygonum cognatum, rat, stomach, ulcer, OXIDATIVE STRESS, ULCER, ACID, ASSAY
  • Ataturk University Affiliated: Yes

Abstract

We investigated the anti-ulcer activity of ethanol extracts of Polygonum cognatum on indomethacin induced gastric damage in rats. We evaluated the number of ulcer areas, oxidant and antioxidant parameters as well as histopathologic features in rat stomach. We measured the total antioxidant status of P. cognatum in concentrations from 1.56-100 mg/ml. P. cognatum extract inhibited indomethacin induced ulcer formation with an effect similar to a 20 mg/kg dose of the standard anti-ulcer drug, esomeprazole. All doses of P. cognatum extract exhibited positive effects on oxidative stress markers and histopathological features in the stomach tissue of rats. We suggest that the antioxidant activity of P. cognatum extract may be responsible for its gastroprotective effect and that P. cognatum extract may be a useful gastroprotective agent.