Effects of Lacidipine, Ramipril and Valsartan on Serum BNP Levels in Acute and Chronic Periods Following Isoproterenol-Induced Myocardial Infarction in Rats

BAYIR Y., ÇADIRCI E., Suleyman H., HALICI Z., Keles M. S.

EURASIAN JOURNAL OF MEDICINE, vol.41, no.1, pp.44-48, 2009 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 1
  • Publication Date: 2009
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.44-48
  • Keywords: Brain natriuretic peptide, Isoproterenol, Lacidipine, Myocardial infarction, Ramipril, Valsartan
  • Ataturk University Affiliated: Yes


Objective. Myocardial infarction (MI) as a result of cardiovascular disease is the principal cause of death in both developed and developing countries. Brain natriuretic peptide (BNP) is an important marker of cardiac failure. Cardioprotective activities of the antihypertensive drugs lacidipine (LAC), ramipril (RAM) and valsartan (VAL), against isoproterenol (ISO)-induced MI, have been determined. However, the levels of BNP, an indicator of left ventricular failure, have not been evaluated.