Development of a New Chitosan Based Nanomaterial for Controlled Delivery of Prilocaine

AKTAS Y., ATİLA A., KADIOĞLU Y.

LATIN AMERICAN JOURNAL OF PHARMACY, cilt.32, sa.7, ss.1048-1052, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 7
  • Basım Tarihi: 2013
  • Dergi Adı: LATIN AMERICAN JOURNAL OF PHARMACY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1048-1052
  • Atatürk Üniversitesi Adresli: Evet

Özet

Prilocaine is a local anaesthetic compound and methemoglobinemia may occur after its administration. In some cases, it may lead to dyspnoea, dysrhythmia, seizures and coma. Chitosan (CS) nanoparticles are potential vehicles for controlled delivery of drugs and have the capacity to protect sensitive bioactive materials from enzymatic and chemical degradation in vivo. The purpose of this study was to prepare and characterize prilocaine-loaded CS nanoparticles and evaluate their potential for reducing side effects in local anaesthetic applications. Prilocaine-loaded CS nanoparticles are evaluated for their particle size, zeta potential, drug loading capacity and release properties. Quantification of the prilocaine was carried out with a validated gas chromatography method. According to the data obtained, these chitosan-based prilocaine nanoparticles May open an interesting perspective for localised delivery of prilocaine, thus reducing side effects.