Low transcriptional activity of PON2 in recurrent abortion: A novel therapeutic agent?

DİKBAŞ L., DUR R., TAŞ İ. H., YAPÇA Ö. E., DİKBAŞ N.

JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, cilt.47, sa.8, ss.379-383, 2018 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 8
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.jogoh.2018.06.006
  • Dergi Adı: JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.379-383
  • Anahtar Kelimeler: Recurrent abortion, PON2, PON3, mRNA, OXIDATIVE STRESS, FREE-RADICALS, EXPRESSION, PARAOXONASE-3, PROTECTS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective. - Oxidative stress has been reported to be associated with various pregnancy complications and to play key roles in many of them. An inadequate level of antioxidant defense may eventually lead to an early pregnancy loss. There is a lack of information about the roles of the PON2 and PON3 enzymes in the etiology of the cases of unexplained recurrent abortus. The aim of our study is to determine and present the data regarding the roles of these enzymes for the first time.