Low transcriptional activity of PON2 in recurrent abortion: A novel therapeutic agent?

DİKBAŞ L., DUR R., TAŞ İ. H., YAPÇA Ö. E., DİKBAŞ N.

JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, vol.47, no.8, pp.379-383, 2018 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 8
  • Publication Date: 2018
  • Doi Number: 10.1016/j.jogoh.2018.06.006
  • Journal Name: JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.379-383
  • Keywords: Recurrent abortion, PON2, PON3, mRNA, OXIDATIVE STRESS, FREE-RADICALS, EXPRESSION, PARAOXONASE-3, PROTECTS
  • Ataturk University Affiliated: Yes

Abstract

Objective. - Oxidative stress has been reported to be associated with various pregnancy complications and to play key roles in many of them. An inadequate level of antioxidant defense may eventually lead to an early pregnancy loss. There is a lack of information about the roles of the PON2 and PON3 enzymes in the etiology of the cases of unexplained recurrent abortus. The aim of our study is to determine and present the data regarding the roles of these enzymes for the first time.