Diffuse Large B Cell Lymphoma Secondary to Rheumatoid Artritis: Case Report

BİLEN Y., ERDEM F., GÜNDOĞDU M., YILDIRIM R.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, cilt.32, sa.6, ss.1754-1757, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 6
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5336/medsci.2011-23797
  • Dergi Adı: TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1754-1757
  • Atatürk Üniversitesi Adresli: Evet

Özet

Lymphoid malignancies are a heterogeneous group of neoplasms originating from B- and T-lymphocytes with an unexplained etiology. Several autoimmune conditions, especially Sjogren syndrome and rheumatoid arthritis (RA) are associated with lymphoma. Immunosuppressiye agents like methotrexate may cause Epstein-Barr virus reactivation that can lead to development of lymphoma. The risk of lymphoma, especially Hodgkin lymphoma, is increased up to 2-3 times in RA patients compared to normal population. The cause of increased risk is independent from the immunosuppressive medication. We report here an unusual case of diffuse large B-cell lymphoma in a patient with RA receiving methotrexate treatment, after obtaining the approval of the informed consent of the patient.