Albumin/creatinine ratio for prediction of 24-hour albumin excretion of >= 2 g in manifest preeclampsia

AL R. A., BÖREKÇİ B., YAPÇA Ö. E., KELEŞ O. N., KADANALI S.

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, cilt.36, sa.3, ss.169-172, 2009 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 3
  • Basım Tarihi: 2009
  • Dergi Adı: CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.169-172
  • Anahtar Kelimeler: Albumin-to-creatinine ratio, Albuminuria, Preeclampsia, Urine creatinine, ROC curve, PROTEIN-CREATININE RATIO, RANDOM URINE SAMPLES, PROTEIN/CREATININE RATIO
  • Atatürk Üniversitesi Adresli: Evet

Özet

Purpose of investigation: To compare whether albumin/creatinine ratios obtained from random or 8-hour urine collected in different periods of day differ in prediction of albumin excretion >= 2 g in 24-hour urine collection in preeclampsia. Methods: From a total of 70 women, 24-hour urine collected by three consecutive periods of eight hours and three random urine samples were taken before each period. The variation of albumin-creatinine ratios in samples across the day was analyzed by the Friedman and inter-assay coefficient variation. For each sample, receiver operator characteristic (ROC) curves were constructed to determine an optimal albumin/creatinine ratio value in the prediction of albuminuria >= 2 g. Results: The albumin/creatinine ratio did not vary significantly over time when all samples pooled. However, there was considerable intra-individual variation in both random and timed urine samples. On ROC analysis, the albumin/creatinine ratio in both random and timed urine samples predicted the 24-hour urine results and there was no difference between samples in prediction of albuminuria >= 2 g. A single optimal cut-off point was not available between samples. The positive and negative predictive values for optimal cut-offs ranged from 48%-88% and 94%-100%, respectively. Conclusions: The random urine albumin/creatinine ratio was a poor predictor for proteinuria >= 2 g in patients with preeclampsia.