Synthesis and evaluation of the biological activities of novel hybrid isoindol-1,3-dione containing an aziridine unit

GÜNDOĞDU Ö., Gumus R., KARATAŞ Ö. F., KARA Y.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.60, sa.6, ss.987-992, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 6
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/jhet.4643
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chemical Abstracts Core, Chimica, EMBASE
  • Sayfa Sayıları: ss.987-992
  • Atatürk Üniversitesi Adresli: Evet

Özet

Aziridine-containing compounds have many biological activities, particularly antitumor, and antibacterial activities, due to the presence of an aziridine ring. The aim of this study was to synthesize four hybrid isoindol-1,3-dione analogues containing aziridine units (8a-d) and evaluate their cytotoxic potential against the A549, MCF7, and PC3 cell lines. A549, MCF7, and PC3 cells exposed to each obtained compound at doses of 5, 25, and 100 mu M were incubated for 24 h and 8c was found to exhibit obvious anticancer activity against all three cancer cell lines. Further apoptosis assays and in vitro wound-healing tests were performed and the results were evaluated.