THAI JOURNAL OF VETERINARY MEDICINE, vol.51, no.3, pp.587-596, 2021 (SCI-Expanded)
The aim of this study is to determine the effects of laparoscopic ovariectomy (LOVE) and conventional open ovariectomy (COVE) methods on early-stage surgical stress parameters [proinflammatory cytokines (TNF-α and IL-6), acute phase proteins (CRP, Hp), inducible nitric oxide synthase (INOS), mitogen activated protein kinase (MAPK14) and cortisol], pain scores and D-Dimer (DD) levels in 36 healthy bitches. Three-port laparoscopic ovariectomy was performed on the LOVE group while routine ovariectomy was performed on the COVE group. Surgical stress parameters and pain scores (University of Melbourne pain scale) were assessed during the pre- (0 hour) and postoperative periods (1st, 3rd, 6th hour and 7 days). DD analyses were performed between 0-1 hours to compare coagulation rates. At the early postoperative stage, operation time, surgical stress, pain scores and DD levels were lower (P<0.05) in the LOVE group compared to the COVE group. No differences were found in terms of surgical stress and pain score between the groups on day 7 post-operation. As a result, we found that LOVE, a minimal invasive method, caused less surgical stress and post-operative pain as well as a shorter operation period compared to COVE and the patients returned to their preoperative activities in a shorter time. Therefore, it was concluded that the three-port LOVE was more advantageous compared to COVE in terms of safety and patient comfort.