Are Serum Interleukin 6 and Surfactant Protein D Levels Associated with the Clinical Course of COVID-19?

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Kerget B. , Kerget F., Koçak A. O. , Kızıltunç A. , Araz Ö., Uçar E. , ...More

Lung, vol.198, no.5, pp.777-784, 2020 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 198 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.1007/s00408-020-00393-8
  • Title of Journal : Lung
  • Page Numbers: pp.777-784
  • Keywords: COVID-19, Interleukin 6, Surfactant protein D, Acute respiratory distress, IL-6 LEVELS


Purpose SARS-CoV-2 (COVID-19) has infected more than 7 million people worldwide in the short time since it emerged in Wuhan, China in December 2019. The aim of this study was to investigate the relationship between serum interleukin 6 (IL-6) and surfactant protein D (SP-D) levels and the clinical course and prognosis of COVID-19. Materials and Methods The study included a total of 108 individuals: 88 patients who were diagnosed with COVID-19 by real-time PCR of nasopharyngeal swab samples and admitted to the Ataturk University Pulmonary Diseases and the Erzurum City Hospital Infectious Diseases department between March 24 and April 15, and 20 asymptomatic healthcare workers who had negative real-time PCR results during routine COVID-19 screening in our hospital. Results Patients who developed macrophage activation syndrome had significantly higher IL-6 and SP-D levels at the time of admission and on day 5 of treatment compared to the other patients (IL-6:p = 0.001 for both; SP-D:p = 0.02,p = 0.04). Patients who developed acute respiratory distress syndrome had significantly higher IL-6 and SP-D levels at both time points compared to those who did not (p = 0.001 for all). Both parameters at the time of admission were also significantly higher among nonsurvivors compared to survivors (IL-6:p = 0.001, SP-D:p = 0.03). Conclusion In addition to IL-6, which has an important role in predicting course and planning treatment in COVID-19, SP-D may be a novel pneumoprotein that can be used in the clinical course, follow-up, and possibly in future treatments.