Possible contribution of the neprilysin/ACE pathway to sepsis in mice


UĞAN R. A. , Un H., Gurbuz M. A. , Kaya G., Kahramanlar A., Aksakalli-Magden Z. B. , ...More

LIFE SCIENCES, vol.258, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 258
  • Publication Date: 2020
  • Doi Number: 10.1016/j.lfs.2020.118177
  • Title of Journal : LIFE SCIENCES

Abstract

Aim: Omapatrilat is an antagonist of angiotensin-converting (ACE) and neprilysin-neuropeptidase (NEP) enzymes. The aim of our study is to show that omapatrilat may have beneficial effects as a treatment for polymicrobial sepsis.