Possible contribution of the neprilysin/ACE pathway to sepsis in mice

Uğan R. A., Un H., Gurbuz M. A., Kaya G., Kahramanlar A., Aksakalli-Magden Z. B., ...More

LIFE SCIENCES, vol.258, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 258
  • Publication Date: 2020
  • Doi Number: 10.1016/j.lfs.2020.118177
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Omapatrilat, Sepsis, Mice, ACE, Neprilysin, ATRIAL-NATRIURETIC-PEPTIDE, ANGIOTENSIN-CONVERTING ENZYME, ACUTE LUNG INJURY, VASOPEPTIDASE INHIBITOR OMAPATRILAT, ACUTE RESPIRATORY-DISTRESS, RAT MODEL, PERMEABILITY, CANDESARTAN, INFARCTION, CYTOKINES
  • Ataturk University Affiliated: Yes

Abstract

Aim: Omapatrilat is an antagonist of angiotensin-converting (ACE) and neprilysin-neuropeptidase (NEP) enzymes. The aim of our study is to show that omapatrilat may have beneficial effects as a treatment for polymicrobial sepsis.