Akademik Veri Yönetim Sistemi
Türk Doğa ve Fen Dergisi, cilt.12, sa.2, ss.138-144, 2023 (Hakemli Dergi)
Long-term exposure to sodium valproate, an anti-epileptic drug, causes toxic effects in tissues, especially by increasing oxidative stress and inflammation. Rutin is a flavanoid with anti- oxidant, anti-inflammatory and anti-apoptotic effects found naturally in many plants. In this study, we aimed to investigate the effects of rutin, a natural anti-oxidant, on sodium valproate- induced spleen tissue damage. 35 male rats were divided into 5 groups as control, sodium valproate, rutin, sodium valproate+Rutin 50 and sodium valproate+Rutin 100 groups. For 14 days, 500 mg/kg dose of sodium valproate and 50 or 100 mg/kg of rutin were administered by oral gavage. On day 15, spleen tissues were removed and biochemical methods, oxidative stress, inflammation and apoptotic parameters were analyzed and histologic analysis was performed. The levels of sodium valproate-induced oxidative stress, inflammation and apoptosis parameters increased in spleen tissues compared to the control group (p<0.05). With routine administration, all of these sodium valproate-induced increases were decreased (p<0.05). It was concluded that rutin has potential protective properties against the toxic effect caused by sodium valproate exposure in spleen tissues.