The lung endothelin system: a potent therapeutic target with bosentan for the amelioration of lung alterations in a rat model of diabetes mellitus

CAYIR, A.; UĞAN, Rüstem; ALBAYRAK, Abdulmecit; KÖSE, Duygu; AKPINAR, Erol; ÇAYIR, Yasemin; Atmaca, H.; BAYRAKTUTAN, Zafer; KARA, Murat

doi:10.1007/s40618-015-0282-y

The lung endothelin system: a potent therapeutic target with bosentan for the amelioration of lung alterations in a rat model of diabetes mellitus

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CAYIR A., UĞAN R. A., ALBAYRAK A., KÖSE D., AKPINAR E., ÇAYIR Y., ...More

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol.38, no.9, pp.987-998, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 38 Issue: 9
Publication Date: 2015
Doi Number: 10.1007/s40618-015-0282-y
Journal Name: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.987-998
Keywords: Bosentan, Lung injury, Endothelin system, Diabetes, RECEPTOR ANTAGONIST BOSENTAN, OXIDATIVE STRESS, POLYMICROBIAL SEPSIS, ETA-RECEPTOR, NITRIC-OXIDE, DOUBLE-BLIND, COMPLICATIONS, DYSFUNCTION, TISSUE, EXPRESSION
Ataturk University Affiliated: Yes

Abstract

Purpose The aim of this study is to show the effect of a new mechanism on endothelin (ET) receptors in the physiopathology of diabetes-related pulmonary injury. We tested the hypothesis that dual ET-1 receptor antagonism via bosentan can reverse diabetes-induced lung injury.