The effectiveness of eugenol against cisplatin-induced ototoxicity A eficácia do eugenol contra a ototoxicidade induzida pela cisplatina


Sakat M. S. , Kılıç K. , Akdemir F. N. E. , Yıldırım S., Eser G., Kızıltunç A.

Brazilian Journal of Otorhinolaryngology, vol.85, no.6, pp.766-773, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 85 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.1016/j.bjorl.2018.07.007
  • Title of Journal : Brazilian Journal of Otorhinolaryngology
  • Page Numbers: pp.766-773
  • Keywords: Cisplatin-induced ototoxicity, Eugenol, DPOAE, Oxidative stress, 8-Hydroxy-2 '-deoxyguanosine, ANTIOXIDANT, INHIBITION

Abstract

Introduction: Ototoxicity refers to cellular damage or function impairment developing in the inner ear in association with any therapeutic agent or chemical substance, and still represents the principal side-effect restricting the use of cisplatin.