Akademik Veri Yönetim Sistemi
ASIAN JOURNAL OF CHEMISTRY, cilt.22, sa.5, ss.3404-3412, 2010 (SCI-Expanded)
A pair of pramoxine-based compounds. K-94 and K-95, which are potential local anesthetic and anticholinergic agents, were synthesized using a previously synthesized Schiff base of 2-diethylamine chloride and potassium carbonate. Of the compounds synthesized, compound K-94 was new. Moreover. R(M), a physicochemical parameter, has been calculated for both compounds in order to investigate the effect of these structural changes on the lipophilic and steric characteristics of these molecules It also provides relevant data for the correlations with structure-activity relationship studies Both of these compounds, phenylimino derivative, K-94. having an R(M) of 0.91 and phenethylimino derivative. K-95. having an R(M) of 0.87, showed similar values with procaine having R(M) value of 0 66.