Comparison of the E test with the CLSI Broth Microdilution Reference Method for Testing Fluconazole against Candida spp. Isolated from Blood Cultures

Coskun M. V., Agan I., UYANIK M. H., HANCI H., ÖZDEN K.

MARMARA PHARMACEUTICAL JOURNAL, cilt.21, sa.2, ss.400-406, 2017 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.12991/marupj.301167
  • Dergi Adı: MARMARA PHARMACEUTICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.400-406
  • Atatürk Üniversitesi Adresli: Evet

Özet

Increased resistance against antifungal agents recently shows the importance of antifungal susceptibility testing especially to Candida spp. isolated from invasive infections. Although the Broth Microdilution (BMD) method has been standardized as an antifungal susceptibility testing by "Clinical and Laboratory Standards Institute (CLSI)", difficulties in the practice of the this method pushed the researchers to seek more practical methods that can be used in routine laboratories. The aim of this study was to compare E-test method with standard BMD method for antifungal susceptibility testing of Candida spp. isolated from blood cultures in our hospital, against fluconazole which is commonly used in the treatment of systemic Candida infections. In addition by the distribution of the accumulated isolates in the process of the study, the most common species of Candida causes Candidemia in our hospital were determined.