Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress

Jung T. W., Kim H., Park S. Y., Cho W., Oh H., Lee H. J., ...More

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol.45, no.11, pp.2181-2191, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 11
  • Publication Date: 2022
  • Doi Number: 10.1007/s40618-022-01866-8
  • Journal Name: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.2181-2191
  • Keywords: Stachydrine, AMPK, HO-1, Inflammation, ER stress, Insulin resistance, ACTIVATED PROTEIN-KINASE, OXIDATIVE STRESS, HEME OXYGENASE-1, ER STRESS, KAPPA-B, PATHOGENESIS, LIVER, FIBROSIS, PATHWAY, SYSTEM
  • Ataturk University Affiliated: Yes

Abstract

Objective Insulin resistance develops due to skeletal muscle inflammation and endoplasmic reticulum (ER) stress. Stachydrine (STA), extracted from Leonurus heterophyllus, has been shown to suppress proliferation and induce apoptosis in breast cancer cells and exert anti-inflammatory properties in the brain, heart, and liver. However, the roles of STA in insulin signaling in skeletal muscle remain unclear. Herein, we examined the impacts of STA on insulin signaling in skeletal muscle under hyperlipidemic conditions and its related molecular mechanisms.