Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation


ÜN H., UĞAN R. A. , GÜRBÜZ M. A. , BAYIR Y. , Kahramanlar A., Kaya G., ...More

LIFE SCIENCES, vol.266, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 266
  • Publication Date: 2021
  • Doi Number: 10.1016/j.lfs.2020.118869
  • Title of Journal : LIFE SCIENCES
  • Keywords: Phloretin, Phloridzin, Cisplatin, Nephrotoxicity, Mice, MAMMALIAN-CELLS, INJURY, HEAT-SHOCK-PROTEIN-70, ANTIOXIDANT, INCREASES, TOXICITY, EFFICACY, KIDNEY, TISSUE, ASSAY

Abstract

Aim: Cisplatin (Cis) is widely used chemotherapeutic and has some serious side effects as nephrotoxicity. Phloretin (PH) and Phloridzin (PZ) are known their anti-oxidant anti-inflammatory effects. We aimed to examine the protective effects of PH and PZ on cisplatin-induced nephrotoxicity.