Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation


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Ün H., Uğan R. A., Gürbüz M. A., Bayır Y., Kahramanlar A., Kaya G., ...More

LIFE SCIENCES, vol.266, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 266
  • Publication Date: 2021
  • Doi Number: 10.1016/j.lfs.2020.118869
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Phloretin, Phloridzin, Cisplatin, Nephrotoxicity, Mice, MAMMALIAN-CELLS, INJURY, HEAT-SHOCK-PROTEIN-70, ANTIOXIDANT, INCREASES, TOXICITY, EFFICACY, KIDNEY, TISSUE, ASSAY
  • Ataturk University Affiliated: Yes

Abstract

Aim: Cisplatin (Cis) is widely used chemotherapeutic and has some serious side effects as nephrotoxicity. Phloretin (PH) and Phloridzin (PZ) are known their anti-oxidant anti-inflammatory effects. We aimed to examine the protective effects of PH and PZ on cisplatin-induced nephrotoxicity.