A novel approach for the synthesis of β-keto esters: One-pot reaction of carboxylic acids with chlorosulfonyl isocyanate
Arkivoc, cilt.6, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 6
- Basım Tarihi: 2020
- Doi Numarası: 10.24820/ark.5550190.p011.209
- Dergi Adı: Arkivoc
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Directory of Open Access Journals
- Anahtar Kelimeler: beta-Keto ester, chlorosulfonyl isocyanate, carboxylic acid, trifluoroacetic acid, one-pot, ACYLATION
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Atatürk Üniversitesi Adresli: Evet
Özet
© AUTHOR(S).β-Keto esters were synthesized by direct carboxylation of various 4- and 5-oxo-carboxylic acid derivatives in the presence of chlorosulfonyl isocyanate in excellent yield under mild conditions. Additionally, optimization conditions were examined for synthesis β-keto esters. Finally, it has been found that trifluoroacetic acid is efficient in DCM under optimized conditions. This efficient one-pot novel method is very usefull, fair price and easy to handle of β-keto esters.