Virtual insights into the quercetin-<i> Melampsora</i> lini-derived effector AvrM14 interaction: An<i> In</i><i> silico</i> exploration of plant defense mechanisms

Shadidizaji A., Cinisli K. T., WARDA M. A. A., ÇİÇEK B., Hacimuftoglu A.

PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY, cilt.129, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 129
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1016/j.pmpp.2023.102200
  • Dergi Adı: PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, Veterinary Science Database
  • Atatürk Üniversitesi Adresli: Evet

Özet

The co-evolutionary struggle between plants and pathogens shapes vital defense mechanisms crucial for survival. AvrM14 selectively removes the 5 ' cap from mRNA, disrupting key aspects of plant mRNA regulation, enhancing the flax rust fungus's infection capabilities. In contrast, quercetin, a plant flavonoid, serves as an antioxidant, stress reliever, and immune protector. This in silico study explores quercetin's inhibition of AvrM14, revealing high-affinity binding to the Nidux domain through molecular docking. Confirming stability in dynamic simulations, this pioneering research establishes quercetin as a functional AvrM14 inhibitor, suggesting its potential as a therapeutic agent against Melampsora lini's harmful impact on plant health.