Ameliorative Effect of Carvacrol on Cisplatin-Induced Reproductive Damage in Male Rats

Aksu E. H. , Kandemir F. M. , Altun S. , Kucukler S. , Çomaklı S. , Ömür A. D.

Journal of Biochemical and Molecular Toxicology, vol.30, pp.513-520, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30
  • Publication Date: 2016
  • Doi Number: 10.1002/jbt.21816
  • Title of Journal : Journal of Biochemical and Molecular Toxicology
  • Page Numbers: pp.513-520
  • Keywords: Cisplatin, Carvacrol, Spermiotoxicity, Apoptosis, Oxidative Stress, OXIDATIVE STRESS, SPERM, EXTRACT, CHEMOTHERAPY, TESTIS, TISSUE, SYSTEM


Cisplatin (CP) treatment causes the damage in male reproductive system. Carvacrol (CARV) is an antioxidant that is naturally found in some plants. We aimed to investigate the effect of CARV on CP-induced reproductive toxicity in male rats. Eighteen adult male Sprague-Dawley rats were used. The controlgroup (n = 6) was treated orally with physiological saline (PS) daily for 14 days and a singleintraperitoneal (IP) PS injection on day 10. The CP group (n = 6) was administered with daily oral PS for 14 daysand a single IP injection of 10 mg/kg CP on day 10. The CARV + CP group(n = 6) was treated with daily 75 mg/kg oral CARV for 14 days and a single IP injection of 10 mg/kg CP on day 10. CP treatment caused the damage on some spermatological parameters (motility, live sperm rate, and abnormal sperm rate), increased the oxidative stress, and induced testicular degeneration and apoptosis. However, CARV treatment mitigates CP-induced reproductive toxicity.