Amiodarone has anti-inflammatory and anti-oxidative properties: An experimental study in rats with carrageenan-induced paw edema


HALICI Z. , Dengiz G. O. , Odabasoglu F. , Suleyman H. , ÇADIRCI E. , HALICI M. B.

EUROPEAN JOURNAL OF PHARMACOLOGY, vol.566, pp.215-221, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 566
  • Publication Date: 2007
  • Doi Number: 10.1016/j.ejphar.2007.03.046
  • Title of Journal : EUROPEAN JOURNAL OF PHARMACOLOGY
  • Page Numbers: pp.215-221
  • Keywords: amiodarone, carrageenan, acute inflammation, myeloperoxidase, anti-oxidant enzyme, TUMOR-NECROSIS-FACTOR, INFLAMMATION, SUPEROXIDE, DRUGS, MYELOPEROXIDASE, GLUTATHIONE, RESPONSES, TOXICITY, ENZYMES

Abstract

Amiodarone is a widely used anti-arrhythmic agent. We have investigated alterations in the glutathione (GSH) level and the activities of anti-oxidative enzymes (superoxide dismutase, catalase, glutathione s-transferase and glutathione reductase) and myeloperoxidase, as marker of acute inflammation, following oral administration of amiodarone and diclofenac in rats with carrageenan-induced paw edema. In the present study, we found that 1) Amiodarone reduced the development of carrageenan-induced paw edema, to a greater degree than diclofenac; 2) Amiodarone and diclofenac alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from edema; 3) Amiodarone and diclofenac ameliorated depressions in the GSH level and the activities of superoxide dismutase and glutathione reductase enzymes caused by carrageenan injection; and 4) All doses of amiodarone and diclofenac caused an amplification in myeloperoxidase activity resulting from induced paw edema. These results suggest that the anti-inflammatory effect of amiodarone on carrageenan-induced acute inflammation can be attributed to its ameliorating effect on the oxidative damage. (c) 2007 Elsevier B.V. All rights reserved.