Paracetamol-induced nephrotoxicity and oxidative stress in rats: the protective role of Nigella sativa.


CANAYAKIN D., BAYIR Y., BAYGUTALP N., KARAOGLAN E., Atmaca H. T., OZGERIS F. B. K., ...More

Pharmaceutical biology, vol.54, no.10, pp.2082-91, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 10
  • Publication Date: 2016
  • Doi Number: 10.3109/13880209.2016.1145701
  • Journal Name: Pharmaceutical biology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2082-91
  • Keywords: Glutathione, kidney, malondialdehyde, superoxide dismutase, ACUTE-RENAL-FAILURE, CHEMICAL-COMPOSITION, POSSIBLE MECHANISM, N-ACETYLCYSTEINE, ACETAMINOPHEN, LIVER, THYMOQUINONE, KIDNEY, ANTIOXIDANT, TOXICITY
  • Ataturk University Affiliated: Yes

Abstract

Context Nigella sativa L. (Ranunculaceae) (NS) is traditionally used to treat many conditions such as inflammation. Objective This study evaluates the effects of NS seeds ethanol extract in paracetamol-induced acute nephrotoxicity in rats.