Association between hepatocyte growth factor (HGF) gene polymorphisms and serum HGF levels in patients with rheumatoid arthritis Romatoid artritli hastalarda serum hepatosit büyüme faktörü (HGF) düzeyleri ile HGF gen polimorfizmleri arasındaki İlişki

KARA F., Yildirim A., Gumusdere M., Karatay S., Yildirim K., BAKAN E.

Eurasian Journal of Medicine, cilt.46, sa.3, ss.176-181, 2014 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 3
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5152/eajm.2014.41
  • Dergi Adı: Eurasian Journal of Medicine
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.176-181
  • Anahtar Kelimeler: Hepatocyte growth factor, HGF intron 13 C/A, HGF intron 14 T/C, polymorphism, rheumatoid arthritis
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by proliferation and insufficient apoptosis of synovial cell, inflammatory cell infiltration, angiogenesis, and destruction of joints. Hepatocyte growth factor (HGF) has many functions, such as regulation of inflammation, angiogenesis, and inhibition of apoptosis. The purpose of this study was to investigate the association between intron 13 C/A and intron 14 T/C HGF gene polymorphisms and serum HGF levels in patients with RA.