The targets of beta-sitosterol as a novel therapeutic against cardio-renal complications in acute renal ischemia/reperfusion damage

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Koc K., Geyikoglu F., Cakmak O., Koca A., Kutlu Z., Aysin F., ...Daha Fazla

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, cilt.394, sa.3, ss.469-479, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 394 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s00210-020-01984-1
  • Dergi Adı: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.469-479
  • Anahtar Kelimeler: Ischemia/reperfusion, Kidney, Heart, beta-Sitosterol, Inflammation, Oxidative stress
  • Atatürk Üniversitesi Adresli: Evet

Özet

This research is the first to use beta-sitosterol on myocardial and renal tissues in renal ischemia/reperfusion (IR) damage. Female Wistar rats were randomly divided into three groups: control (sham), renal IR (50 min ischemia - 3 h reperfusion), and renal IR + 150 mg/kg/p.o. beta-sitosterol (the rats were treated with beta-sitosterol orally once 1 h before the IR procedure). beta-Sitosterol pretreatment caused an increase in superoxide dismutase and glutathione activities and a decrease in malondialdehyde levels in the kidney and heart. Moreover, it alleviated histopathological changes and downregulated the levels of tumor necrosis factor-alpha and interleukin-6 and upregulated the levels of endothelial nitric oxide synthase. As conclusion, the potential of beta-sitosterol for renal and cardiac necrosis and apoptosis appears to act by limiting inflammatory response and oxidative stress. Thus, the potential of this compound is noteworthy and may serve as a potential therapeutic in the treatment of acute organ damages due to renal IR.