Useful agents against aflatoxin B-1 - antibacterial azomethine and Mn(III) complexes involving L-Threonine, L-Serine, and L-Tyrosine

Anar M., Ozkan E. H., Ogutcu H., AĞAR G., Sakiyan I., Sari N.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.44, sa.3, ss.853-858, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/21691401.2014.991792
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.853-858
  • Anahtar Kelimeler: antimicrobial properties, aflatoxin B, Mn(III) complexes, mutagenicity, AMINO-ACIDS, EPOXIDATION, GLUTAMINE
  • Atatürk Üniversitesi Adresli: Evet

Özet

The present study is focused on evaluating the antimutagenic properties of Schiff bases and Mn(III) complexes with L-Threonine, L-Serine and L-Tyrosine, which have antimicrobial activity. These six compounds were investigated for antimutagenic properties against Aflatoxin B (AFB) by the micronucleus (MN) assay in a human lymphocyte cell culture in vitro. The protective role of these compounds against AFB-induced MN is probably related to its doses. A mechanism has been proposed to reduce the effect of AFB.