Tip I Ve Tip II Diyabetlilerde Açlık Kan Glukoz Düzeyi ile Eritrosit İçi Antioksidan ve Selenyum Düzeyleri Arasındaki İlişki

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Özkan H. İ., Bakan N., Gül M. A.

32. Ulusal Biyokimya Kongresi, Gaziantep, Türkiye, 27 - 31 Ekim 2021, ss.61

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Gaziantep
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.61
  • Atatürk Üniversitesi Adresli: Evet

Özet

BACKGROUND AND AIM: Diabetes Mellitus (DM) is a metabolic disease characterized by insulin deficiency or insulin ineffectiveness resulting from impaired insulin synthesis. Constantly high blood glucose levels cause the formation of free radicals. The aim of this study is to examine the relationships between DM and blood glucose, antioxidants and selenium levels. METHODS: In patients with Type I (n=30) and Type II (n=70) Diabetes Mellitus, blood glucose levels, SOD, CAT, GSH-Px activities were determined by spectrophotometric measurement. Selenium (Se) level was measured in serum by ICP-MS device and the results were compared with control groups (n=20, n=30). RESULTS: In patients with type I DM (n=30), blood glucose levels and GSHPx were found to be significantly higher when compared to the control group (p< 0.05). No statistically significant difference was found in SOD, CAT and Se levels. When compared with the control group, patients with type II DM (n=70) had significantly higher blood glucose levels and significantly lower SOD, CAT, GSH-Px and Se values (p< 0.05). CONCLUSIONS: Hem Tip I DM’de hem de Tip II DM’de artan glukoz seviyesinin, serbest radikallerin meydana gelme mekanizmalarini aktive ettigi ve serbest radikallerin ortadan kaldirilmasini saglayan antioksidan savunma sisteminin aktivasyonuna neden olabilecegi kanisini ortaya koymaktadir. Keywords: Antioxidants, Diabetes Mellitus, Oxidative stress, Free radicals,Selenium