Akademik Veri Yönetim Sistemi
Tez Türü: Tıpta Uzmanlık
Tezin Yürütüldüğü Kurum: Akdeniz Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Türkiye
Tez Danışmanı: Sevtap Velipaşaoğlu
Tezin Onay Tarihi: 2004
Tezin Dili: Türkçe
Desteklendiği Program: YÖK 100/2000 Programı
Özet:
Hepatitis A (HAV) is an enteric viral disease which courses a wide clinical spectrum. Although HAV infection can be seen all over the world, the prevalence of the disease varies greatly between countries, different regions in the same country, and age groups. A comprehensive seroprevalence study has not been conducted in Antalya before. In this study, we aimed to determine the HAV-IgG seroprevalence in children of different socioeconomic levels and age groups living in the city center of Antalya and to determine the factors affecting this seroprevalence.
The city center of Antalya is divided into three regions as rural, urban and shantytowns. In our study, one health center from each region was determined by draw method. All children in the 1-15 age group living in that region were determined from household identification cards and the study group was determined by random sampling method. A questionnaire was filled in to evaluate the factors affecting seroprevalence for each child. The presence of HAV-IgG in serum samples was investigated using the micro-ELISA technique.
A total of 555 children were included in the study, and 418 of them were found to be HAV-IgG negative (75.3%) and 137 positive (24.7%). 56.9% of the HAV-IgG positive children lived in the slum areas, 33.6% lived in the urban areas, and 9.5% in the rural areas. HAV-IgG was detected as positive in 26% of children living in rural areas, 13.2% of children living in urban areas and 49.7% of children living in slum areas (p<0.0001).
While HAV-IgG seropositivity was 17.3% in the 1-4 age group, this value increased up to 31.4% in the 10-14 age group. The difference between these two age groups was statistically significant (p<0.01).
Contact with HAV begins in childhood and increases with age. Considering the change in HAV epidemiology, it should be considered that young adults and adults will be less exposed to HAV, and sensitive individuals should be informed that they can be protected by vaccination.