Effect of the combination of <i>Lactobacillus acidophilus </i>(probiotic) with vitamin K3 and vitamin E on <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>: An <i>in vitro</i> pathogen model

ÇELEBİ Ö., TAGHIZADEHGHALEHJOUGHI A., ÇELEBİ D., Mesnage R., Golokhvast K. S., Arsene A. L., ...Daha Fazla

MOLECULAR MEDICINE REPORTS, cilt.27, sa.6, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 6
  • Basım Tarihi: 2023
  • Doi Numarası: 10.3892/mmr.2023.13006
  • Dergi Adı: MOLECULAR MEDICINE REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Chemical Abstracts Core, MEDLINE
  • Anahtar Kelimeler: antioxidant activity, Escherichia coli, gut microbiota, methicillin-resistant Staphylococcus aureus, probiotic, vitamins, LACTIC-ACID BACTERIA, PROBIOTIC LACTOBACILLI, ADHESION, STRAINS, PERMEABILITY, ADHERENCE, RESERVOIR, PRODUCT, GROWTH, CELLS
  • Atatürk Üniversitesi Adresli: Evet

Özet

The gut microbiota plays a key role in maintaining health and regulating the host's immune response. The use of probiotics and concomitant vitamins can increase mucus secretion by improving the intestinal microbial population and prevent the breakdown of tight junction proteins by reducing lipopolysaccharide concentration. Changes in the intestinal microbiome mass affect multiple metabolic and physiological functions. Studies on how this microbiome mass and the regulation in the gastrointestinal tract are affected by probiotic supplements and vitamin combinations have attracted attention. The current study evaluated vitamins K and E and probiotic combinations effects on Escherichia coli and Staphylococcus aureus. Minimal inhibition concentrations of vitamins and probiotics were determined. In addition, inhibition zone diameters, antioxidant activities and immunohistochemical evaluation of the cell for DNA damage were performed to evaluate the effects of vitamins and probiotics. At the specified dose intervals, L. acidophilus and vitamin combinations inhibit the growth of Escherichia coli and Staphylococcus aureus. It could thus contribute positively to biological functions by exerting immune system-strengthening activities.