Role of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in rats

Ozkaya A., Sahin Z., Kuzu M., SAĞLAM Y. S., ÖZKARACA M., Uckun M., ...Daha Fazla

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, cilt.124, sa.1, ss.80-87, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 124 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/13813455.2017.1364772
  • Dergi Adı: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.80-87
  • Anahtar Kelimeler: Geraniol, lead acetate, oxidative stress, carboxylesterase, liver, GLUTATHIONE S-TRANSFERASES, OXIDATIVE STRESS, ESSENTIAL OILS, ICP-MS, INHIBITION, DISEASE, TISSUE, DNA, HEPATOTOXICITY, NARINGENIN
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, the effect of geraniol (50 mg/kg for 30 d), a natural antioxidant and repellent/antifeedant monoterpene, in a rat model of lead acetate-induced (500 ppm for 30 d) liver damage was evaluated. Hepatic malondialdehyde increased in the lead acetate group. Reduced glutathione unchanged, but glutathione S-transferase, glutathione reductase, as well as carboxylesterase activities decreased in geraniol, lead acetate and geraniol+lead acetate groups. 8-OhDG immunoreactivity, mononuclear cell infiltrations and hepatic lead concentration were lower in the geraniol+lead acetate group than the lead acetate group. Serum aspartate aminotransferase and alanine aminotransferase activities increased in the Pb acetate group. In conclusion, lead acetate causes oxidative and toxic damage in the liver and this effect can reduce with geraniol treatment. However, we first observed that lead acetate, as well as geraniol, can affect liver carboxylesterase activity.