A novel therapeutics agent: antioxidant effects of hydroxylfasudil on rat kidney and liver tissues in a protamine sulphate-induced cystitis rat model; preliminary results

BOZKURT A., BUDAK H., Erol H. S., Can S., Mercantepe T., Akin Y., ...Daha Fazla

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.46, ss.9-14, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/21691401.2018.1449120
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.9-14
  • Anahtar Kelimeler: Interstitial cystitis, hydroxyfasudil, expression, enzyme activity, kidney, liver, RHO-KINASE INHIBITOR, OXIDATIVE STRESS, INTERSTITIAL CYSTITIS, LIPID-PEROXIDATION, BLADDER, EXPRESSION, INFLAMMATION, TOXICITY, FASUDIL, IMPACT
  • Atatürk Üniversitesi Adresli: Evet

Özet

Cystitis is defined as an inflammation of the bladder caused by a bacterial infection, and it can be dangerous and painful when it spreads through the internal organs. In this study, antioxidant effects of hydroxylfasudil (HF) at the enzymatic and molecular level on kidney and liver tissues in cystitis rat model, which is caused by inflammation of the rat bladder with a protamine sulphate (PS), was examined. Quantitative changes of reduced glutathione (GSH) and lipid peroxidation (LPO) levels, which are a marker for oxidative stress, were determined in rat kidney and liver tissues for each groups. And then molecular and biochemical impact of HF treatment on antioxidant enzymes including superoxide dismutase (SOD) and catalase (CAT) in cystitis model were studied. The results suggest that HF could be beneficial to the renal and hepatic antioxidant system. Thus, HF might be used as a novel therapeutics agent to eliminate interstitial cystitis.