Synthesis, Characterization, and Antioxidant and Anticancer Activity of 1,4-Disubstituted 1,2,3-triazoles

Sahin I., ÖZGERİŞ F. B., KÖSE M., BAKAN E., TÜMER F.

JOURNAL OF MOLECULAR STRUCTURE, cilt.1232, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1232
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.molstruc.2021.130042
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, INSPEC
  • Anahtar Kelimeler: Triazole, X-ray structure, Anticancer, Antioxidant activity
  • Atatürk Üniversitesi Adresli: Evet

Özet

This manuscript describes the synthesis, characterization, antioxidant and anticancer activities of the six 1,2,3-triazole derivatives (7a, 7b, 8a, 8b, 9a and 9b) containing a 1,4-disubstitue. All compounds were characterized by H-1 (C-13) NMR, FTIR spectroscopies and elemental analysis. The crystal structures of triazole derivatives (7b, 8a, and 9a) were studied by X-ray diffraction studies. The compounds were screened for their radical scavenging capabilities and the compounds showed comparable antioxidant activities to standard antioxidants. Moreover, the compounds were tested for their cytotoxicity profiles against Hela cancer cell line. Compounds 7a (IC50 values 10.8 mu g/mL), 7b (IC50 values 8.8 mu g/mL), and 8a (IC50 values 11.7 mu g/mL) showed considerable anticancer activity against Hela cell line. (C) 2021 Elsevier B.V. All rights reserved.