An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response

GÜLER M. C., TANYELİ A., EKİNCİ AKDEMİR F. N., ERASLAN E., ÖZBEK ŞEBİN S., GÜZEL ERDOĞAN D., ...Daha Fazla

EURASIAN JOURNAL OF MEDICINE, cilt.54, 2022 (ESCI) identifier identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 54
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5152/eurasianjmed.2022.22293
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Anahtar Kelimeler: Inflammatory response, ischemia-reperfusion injury, oxidative stress, reactive oxygen species, REACTIVE OXYGEN, NECROSIS, MYELOPEROXIDASE, MECHANISMS, INTERLEUKIN-1-BETA, PATHOPHYSIOLOGY, METABOLISM, AUTOPHAGY, PATHWAY, BIOLOGY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Ischemia-reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia-reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia-reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive oxygen species, occur during ischemia-reperfusion. There are several ways to investigate these values through biochemical and histopathologic findings. Malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, interleukin 6, interleukin 1 ss, tumor necrosis factor alpha, caspase-3, nuclear factor-kappa ss, and LC3B (microtubu le-associated protein light chain 3, LC3) can be evaluated among these indicators.