An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response
EURASIAN JOURNAL OF MEDICINE, cilt.54, 2022 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 54
- Basım Tarihi: 2022
- Doi Numarası: 10.5152/eurasianjmed.2022.22293
- Dergi Adı: EURASIAN JOURNAL OF MEDICINE
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Anahtar Kelimeler: Inflammatory response, ischemia-reperfusion injury, oxidative stress, reactive oxygen species
- Atatürk Üniversitesi Adresli: Evet
Özet
Ischemia-reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia-reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia-reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive oxygen species, occur during ischemia-reperfusion. There are several ways to investigate these values through biochemical and histopathologic findings. Malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, interleukin 6, interleukin 1 ss, tumor necrosis factor alpha, caspase-3, nuclear factor-kappa ss, and LC3B (microtubu le-associated protein light chain 3, LC3) can be evaluated among these indicators.