The effects of Panax ginseng and Spirulina platensis on hepatotoxicity induced by cadmium in rats

Karadeniz A., Cemek M., ŞİMŞEK N.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, cilt.72, sa.1, ss.231-235, 2009 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 1
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.ecoenv.2008.02.021
  • Dergi Adı: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.231-235
  • Anahtar Kelimeler: Spirulina platensis, Panax ginseng, Cadmium, Hepatic damage, Rat, ANTIOXIDANT DEFENSE SYSTEM, INDUCED LIPID-PEROXIDATION, SUPEROXIDE-DISMUTASE, VITAMIN-E, LIVER, ERYTHROCYTES, GLUTATHIONE, CATALASE, TISSUES, PLASMA
  • Atatürk Üniversitesi Adresli: Evet

Özet

Cadmium is an environmental and industrial cumulative pollutant that affects many organs, specially the liver. The protective effect of Spirulina platensis and Panax ginseng on cadmium-induced oxidative stress and hepatotoxicity was evaluated in adult female Wistar albino rats. At the end of the 1-month experimental period, all animals were fasted for 12 h and liver samples were taken for the determination of malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and nitric oxide (NO) levels. S. platensis and P. ginseng treatments showed marked decrease lipid peroxidation and increase of the endogenous antioxidants levels. The cadmium-induced histopathological changes were also minimized with the tested extracts. These results suggest that S. platensis and P. ginseng might play a role in reducing the toxic effect of cadmium and its antioxidant properties seem to mediate such a protective effect. (C) 2008 Elsevier Inc. All rights reserved.