Simultaneous Determination of Estradiol Valerate and Medroxyprogesterone Acetate in a Tablet Formulation by Gas Chromatography-Mass Spectrometry

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YILMAZ B.

ANALYTICAL SCIENCES, cilt.26, sa.3, ss.391-393, 2010 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.2116/analsci.26.391
  • Dergi Adı: ANALYTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.391-393
  • Atatürk Üniversitesi Adresli: Evet

Özet

A new and simple gas chromatography-mass spectrometry (GC-MS) method has been developed for simultaneous determination of estradiol valerate (EV) and medroxyprogesterone acetate (MPA) in a tablet formulation. The validation of the proposed method was carried out for selectivity, linearity, accuracy, precision, recovery, limits of detection and quantification. The developed method can be used for routine quality control (QC) analysis of titled drugs in combination in tablet formulation.