The protective effects of epigallocatechin gallate on lipopolysa ccharide-induced hepatotoxicity: an in vitro study on Hep3B cells
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol.19, no.5, pp.483-489, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 19 Issue: 5
- Publication Date: 2016
- Journal Name: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.483-489
- Keywords: Cytokines, Epigallocatechin gallate, Hep3B, Lipopolysaccharide, Oxidative stress, GREEN TEA POLYPHENOL, ACUTE LIVER-FAILURE, OXIDATIVE STRESS, ANTIOXIDANT ENZYMES, HUMAN HEPATOCYTES, HEPG2 CELLS, RAT-LIVER, (-)-EPIGALLOCATECHIN-3-GALLATE, INTERLEUKIN-6, MECHANISMS
- Ataturk University Affiliated: Yes
Abstract
Objective(s): In the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (EGCG) on lipopolysaccharide (LPS)-induced hepatotoxicity by using Hep3B human hepatoma cells. Specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of LPS-associated cytotoxicity. Consequently, the hepatocellular carcinoma cell line Hep3B was chosen as a model for investigation of LPS toxicity and the effect of EGCG on LPS-exposed cells.