The protective effects of epigallocatechin gallate on lipopolysa ccharide-induced hepatotoxicity: an in vitro study on Hep3B cells

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Karamese M., Guvendi B., Karamese S. A., CINAR I., Can S., Erol H. S., ...Daha Fazla

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, cilt.19, sa.5, ss.483-489, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 5
  • Basım Tarihi: 2016
  • Dergi Adı: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.483-489
  • Anahtar Kelimeler: Cytokines, Epigallocatechin gallate, Hep3B, Lipopolysaccharide, Oxidative stress, GREEN TEA POLYPHENOL, ACUTE LIVER-FAILURE, OXIDATIVE STRESS, ANTIOXIDANT ENZYMES, HUMAN HEPATOCYTES, HEPG2 CELLS, RAT-LIVER, (-)-EPIGALLOCATECHIN-3-GALLATE, INTERLEUKIN-6, MECHANISMS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective(s): In the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (EGCG) on lipopolysaccharide (LPS)-induced hepatotoxicity by using Hep3B human hepatoma cells. Specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of LPS-associated cytotoxicity. Consequently, the hepatocellular carcinoma cell line Hep3B was chosen as a model for investigation of LPS toxicity and the effect of EGCG on LPS-exposed cells.