Akademik Veri Yönetim Sistemi
JOURNAL OF MOLECULAR HISTOLOGY, cilt.57, sa.2, 2026 (SCI-Expanded, Scopus)
The present study evaluated Polygonum cognatum extract (PCE) as a therapeutic agent for diabetes treatment. The research used twenty-four Sprague-Dawley male rats which weighed between 250-300 g and were 90 days old. The researchers distributed the 24 rats into four groups which included Control and Diabetes Mellitus (DM) and PCE and DM + PCE. The DM and DM + PCE groups received streptozotocin (STZ) as a single dose to create diabetes in their animals. The solution of STZ required dissolution in a 0.1 M cold citrate buffer which had a pH of 4.5 before i.p. injection. The researchers administered PCE at a dose of 60 mg/kg. The researchers administered PCE through gavage at a daily dose of 10 mg/kg which patients received orally (p.o.) The rats received the treatment for 20 days. The researchers performed rat sacrifices to obtain blood samples and pancreas and liver tissue specimens. The diabetes group showed elevated liver enzyme levels and lipid profile parameters and malondialdehyde (MDA) compared to the Control and PCE groups. The diabetes group showed elevated MDA levels and decreased high-density lipoprotein cholesterol (HDL-C) and glutathione (GSH) concentrations together with reduced glutathione peroxidase (GPx) and superoxide dismutase (SOD) and catalase (CAT) enzyme activities. The combination of PCE with DM led to reduced glucose levels and decreased liver enzyme activity and lipid profile and MDA concentrations and elevated HDL-C and GSH levels and enhanced GPx and SOD and CAT activities. PCE downregulated the expression of caspase-3 and nuclear factor kappa B (NF-kappa B) and B-cell lymphoma 2 (Bcl-2) associated X-protein (Bax) and toll like receptor 4 (TLR-4) but it increased the expression of Bcl-2 and nuclear factor erythroid 2-related factor 2 (Nrf-2) and heme oxygenase-1 (HO-1). The research showed that PCE treatment resulted in decreased blood sugar levels and better liver enzyme and lipid profile results and decreased lipid peroxidation and enhanced antioxidant enzyme activities and reduced oxidative stress in DM rats according to biochemical and histopathological results.