PROTECTIVE EFFECT OF ROYAL JELLY ON SOME BIOCHEMICAL PARAMETERS IN CADMIUM-TREATED ALBINO MICE

ÇAVUŞOĞLU K., YAPAR K., YALÇIN E., ORUÇ E.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.19, sa.10, ss.2164-2169, 2010 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 10
  • Basım Tarihi: 2010
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2164-2169
  • Anahtar Kelimeler: Cadmium toxicity, Biochemical parameters, Liver and kidney pathology, Royal jelly, RATS, TOXICITY, HONEYS, CELL, RJ
  • Atatürk Üniversitesi Adresli: Evet

Özet

In the present study, the protective role of Royal Jelly (RJ) on cadmium-induced toxicity in albino mice was investigated. The mice were divided into six groups. The control group received tap water, mice of treatment groups received 2 mg/kg body weight cadmium and two different doses of RJ (100 and 250 mg/kg b. wt) for 6 weeks by oral gavage. The levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), blood urea nitrogen (BUN) and creatinine were evaluated. In addition, histopathological changes in liver and kidneys were investigated. Serum levels of AST, ALT, ALP, BUN and creatinine in mice receiving cadmium alone significantly increased compared to the other groups (p<0.05). Treatment with RJ produced amelioration in serum biochemical indices according to cadmium group. Each dose of RJ provided protection against cadmium toxicity, and its strongest protective effect was observed at a dose of 250 mg/kg b. wt. In conclusion, RJ can act as a protector agent against cadmium-induced damages of liver and kidney.