Atıf İçin Kopyala
Zeynal M., Şahin M. H.
New Trends in Medicine Sciences, cilt.4, sa.2, ss.73-82, 2023 (Hakemli Dergi)
Özet
Background: The oculomotor nerve root's medial aspect in the cisternal space is closely associated with the posterior communicating artery and receives blood supply from it. This study investigates whether ischemic damage to oculomotor nerve roots results from posterior communicating artery spasm in subarachnoid hemorrhages.
Methods: A total of 18 rabbits participated in this study. Baseline pupil diameters were measured using sunlight and ocular tomography. Rabbits were divided into control (GI, n=5), SHAM (GII, n=5; 0.75 cc serum physiologic injection), and subarachnoid hemorrhage-induced groups (GIII, n=8; 0.75 cc autolog blood injection). Pupil diameters were re-measured after the experiment and daily for three weeks. The animals were observed for one week before euthanasia. The posterior communicating artery vasospasm index (VSI) was determined using the wall surface/lumen surface ratio. Stereological methods were employed to examine the normal and degenerated axon densities of the oculomotor nerves. The Kruskal-Wallis and Mann-Whitney U tests were used to evaluate degenerated axon density (n/mm2) and VSI values. A p-value of less than 0.005 was considered significant.
Results: Degenerated axon numbers (n/mm2) and VSI values of the posterior communicating artery were as follows: 3±1/0.936±0.212 in GI; 18±4/1.578±0.235 in GII; and 212±34/2.515±0.347 in GIII. The p-values were p