Sister chromatid exchange analysis in patients exposed to low dose of iodine-131 for thyroid scintigraphy
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, cilt.393, sa.3, ss.259-262, 1997 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 393 Sayı: 3
- Basım Tarihi: 1997
- Doi Numarası: 10.1016/s1383-5718(97)00110-1
- Dergi Adı: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.259-262
- Atatürk Üniversitesi Adresli: Hayır
Özet
To determine the genotoxic risk associated with diagnostic exposure to low doses of iodine 131 (I-131), sister chromatid exchange (SCE) analysis was performed in lymphocytes of 18 non-smoking women who received 370 kBq (10 mu Ci) intravenous I-131 sodium iodide as an adjuvant for scintigraphy for diagnosing thyroid nodularity. SCE frequencies were measured before and after I-131 administration. SCE results in the pre-treated phase were regarded as control. Although SCE values 24 h after I-131 administration did not show a significant increment (p > 0.05), there was a significant increase 72 h after treatment (p < 0.05). These results indicate that genetic damage might be induced by low dose of I-131. (C) 1997 Elsevier Science B.V.