Higher number of microplastics in tumoral colon tissues from patients with colorectal adenocarcinoma

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Çetin M., Demirkaya Miloğlu F., Kılıç Baygutalp N., Ceylan O., Yıldırım S., Eser G., ...Daha Fazla

ENVIRONMENTAL CHEMISTRY LETTERS, cilt.21, sa.2, ss.639-646, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s10311-022-01560-4
  • Dergi Adı: ENVIRONMENTAL CHEMISTRY LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, Environment Index, Pollution Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.639-646
  • Anahtar Kelimeler: ATR-FTIR spectroscopy, Raman spectroscopy, Colorectal cancer, Health, Microplastics, Pollution, HUMAN HEALTH, FTIR
  • Atatürk Üniversitesi Adresli: Evet

Özet

Microplastics have been detected in marine and terrestrial ecosystems, yet the toxic effects of microplastics on living organisms are poorly known. In particular, there is few knowledge on the relationship between microplastic exposure and human cancer. Here we studied the occurrence of microplastics in tumoral and non-tumoral colon tissues of patients diagnosed with colorectal adenocarcinoma, and in colon tissues of subjects not diagnosed with colorectal cancer, as control. Microplastics were analyzed by attenuated total reflection-Fourier-transform infrared and Raman spectroscopies. Results show that the number of microplastics in tumoral colon tissues is higher than the number of microplastics in non-tumoral colon tissues or control. The particle size of microplastics extracted from colon tissues ranges from 1 to 1299 mu m. The microplastics included polyethylene, poly(methyl methacrylate), and Nylon (polyamide). Overall, our findings suggest a possible connection between colorectal cancer and microplastic exposure.