Serum NOX1 and Raftlin as New Potential Biomarkers of Interest in Schizophrenia: A Preliminary Study

Hursitoglu O., Kurutas E. B., Strawbridge R., Uygur Ö. F., Yildiz E., Reilly T. J.

NEUROPSYCHIATRIC DISEASE AND TREATMENT, cilt.18, ss.2519-2527, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18
  • Basım Tarihi: 2022
  • Doi Numarası: 10.2147/ndt.s385631
  • Dergi Adı: NEUROPSYCHIATRIC DISEASE AND TREATMENT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Psycinfo, Directory of Open Access Journals
  • Sayfa Sayıları: ss.2519-2527
  • Anahtar Kelimeler: oxidative stress, oxidant, neuroinflammation, reactive oxygen species, lipid raft, diagnostic performance, COUPLED ESTROGEN-RECEPTOR, OXIDATIVE STRESS, DIAGNOSTIC PERFORMANCE, NITROSATIVE STRESS, DRUG-NAIVE, LIPID RAFT, TNF-ALPHA, PROTEIN, CYTOKINE, DEPRESSION
  • Atatürk Üniversitesi Adresli: Evet

Özet

Introduction: There is increasing evidence that oxidative stress (OS) and neuroinflammation play a role in the neuroprogression of schizophrenia (SCZ). Promising novel candidates which have been proposed in the search for biomarkers of psychotic illness include NADPH oxidase 1,2 (NOX1,2) and raftlin. NOX1 from the NOX family is the main source of physiological reactive oxygen species (ROS) and raftlin, the main lipid raft protein, is associated with inflammatory processes. The aim of the present study was to evaluate serum NOX1 and raftlin levels in chronic stable patients with SCZ. Methods: We measured serum NOX1 and raftlin levels from 45 clinically stable patients with SCZ and 45 healthy controls (HCs) matched for age, sex, and body-mass index. The Positive and Negative Syndrome Scale was applied to the patient group to evaluate the severity of psychotic symptoms. Results: NOX1 and raftlin levels in the patients were statistically significantly higher than the HCs (NOX1 p<0.001, raftlin p<0.001). Both parameters showed very good diagnostic performance (NOX1 AUC = 0.931, raftlin AUC = 0.915). We obtained positive and significant correlations between serum levels of both biomarkers and symptom severity. Discussion: This preliminary study indicating elevations in serum NOX1 and raftlin levels in patients with SCZ supports the importance of OS and inflammatory processes in the etiopathogenesis of the illness.