Olfactory bulbectomy leads to prolonged induction phase of sevoflurane anesthesia in rats

AHISKALIOĞLU A., KANAT A., AYDIN M. D., KAZDAL H., Kocak N., ÖZMEN S.

Medical Gas Research, cilt.14, sa.1, ss.33-37, 2024 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.4103/2045-9912.378881
  • Dergi Adı: Medical Gas Research
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.33-37
  • Anahtar Kelimeler: anesthesia, fila olfactoria, induction time, nose-to-brain delivery, olfactory bulb, olfactory bulbectomy, sevoflurane, transport pathway, volatile anesthetics
  • Atatürk Üniversitesi Adresli: Evet

Özet

The effect of olfactory bulb lesions on the induction time of sevoflurane has never been studied. We aimed to investigate this issue. In this study, we found that the volume of olfactory bulbs and the pore of the fila olfactoria were significantly lower with the fibrosis of olfactory bulbs in animals subjected to olfactory bulbectomy. Volatile anesthetics induction times were measured in all groups. Prolonged induction was observed in olfactory bulbectomy group. It was concluded that increased induction times of sevoflurane may be due to the olfactory bulb lesion.