A Novel Method for the Synthesis of Newfangled Asymmetric Schiff Bases from -amino Acids under Ultrasonic Conditions and in Aqueous Medium
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, cilt.63, sa.9, ss.808-817, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 63 Sayı: 9
- Basım Tarihi: 2016
- Doi Numarası: 10.1002/jccs.201600094
- Dergi Adı: JOURNAL OF THE CHINESE CHEMICAL SOCIETY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.808-817
- Anahtar Kelimeler: Chirality, Amino acids, Schiff bases, Aldehydes, BETA-LACTAMS, IMINES, DERIVATIVES, COMPLEXES, CATALYSTS, ANTIBACTERIAL, ANTIFUNGAL, AGENTS, WATER
- Atatürk Üniversitesi Adresli: Evet
Özet
Chiral Schiff bases were obtained at high yields via a novel technique. Aryl aldehydes and chiral -amino acids were treated (1) in the presence of H3PO4 in ethanol at 80 degrees C for 24 h, and (2) in the presence of K2CO3 under ultrasonic conditions in an aqueous ethanol medium within 5 min with yields reaching up to 96%. The results showed that the presented methodology under ultrasonic conditions was effective, practical, and eco-friendly compared to that using an acidic medium. The corresponding asymmetric Schiff bases were synthesized for the first time, and were characterized by H-1 and C-13 nuclear magnetic resonance and infrared spectroscopy and high-resolution mass spectrometry.