Anti-inflammatory effects of selective COX-2 inhibitors

Suleyman H., Demircan B., Karagoz Y., Oztasan N., Suleyman B.

POLISH JOURNAL OF PHARMACOLOGY, vol.56, no.6, pp.775-780, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 6
  • Publication Date: 2004
  • Journal Name: POLISH JOURNAL OF PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.775-780
  • Ataturk University Affiliated: No

Abstract

In this study, effects of rofecoxib, celecoxib, nimesulide on the acute phase of inflammation were studied in the carrageenan-induced paw edema model and their influence on the chronic phase of inflammation was evaluated in the cotton pellet granuloma tests. Additionally, effects of these drugs on capillary vascular permeability were examined in the hyaluronidase test and were compared with that of indomethacin (nonselective COX inhibitor).