Synthesis, spectroscopic properties, crystal structures, antioxidant activities and enzyme inhibition determination of Co(II) and Fe(II) complexes of Schiff base

Buldurun K., Turan N., Bursal E., Mantarcı A., Turkan F., Taslimi P., ...Daha Fazla

Research on Chemical Intermediates, cilt.46, sa.1, ss.283-297, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s11164-019-03949-3
  • Dergi Adı: Research on Chemical Intermediates
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, Environment Index
  • Sayfa Sayıları: ss.283-297
  • Anahtar Kelimeler: Schiff base, Metal complexes, Carbonic anhydrase, Antioxidant activity, Enzyme inhibition, XRD analysis, TRANSITION-METAL-COMPLEXES, CARBONIC-ANHYDRASE, X-RAY, ANTIMICROBIAL ACTIVITIES, DNA-BINDING, BIOLOGICAL EVALUATION, POLYPHENOL CONTENT, MOLECULAR DOCKING, DFT CALCULATIONS, ACETYLCHOLINESTERASE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Considering the importance of metal complexes in the development of medical science, two different Schiff base Fe(II) and Co(II) metal complex compounds were synthesized with Schiff base obtained through the condensation of 1-(4-aminophenyl)ethanone with 2-hydroxy-3-methoxybenzaldehyde. The reactions of the ligand with Co(II) and Fe(II) metal ions enabled six coordination compounds with octahedral geometries. The novel metal complexes were characterized by IR, elemental analyses, magnetic susceptibility, mass spectra, UV-Vis, thermogravimetry-differential thermal analysis (TGA-DTA) and X-ray diffraction analysis. The antioxidant properties of the new compounds were investigated using different in vitro assays. Moreover, enzyme inhibition of derivatives complexes against carbonic anhydrase I and II isoenzymes (CA I and II) and acetylcholinesterase (AChE) was evaluated. The best inhibitor complex for CA I and II isoenzymes was the Fe(II) complex with K-i values of 52.83 +/- 11.52 and 63.34 +/- 8.88, respectively.