Akademik Veri Yönetim Sistemi
Journal of advances in vetbio science and techniques, cilt.9, sa.2, ss.87-95, 2024 (Hakemli Dergi)
We were aimed to investigate the effect of ginger (Zingiber officinale) essential oil on catalase release in rat kidney tissue by histopathological and immunohistochemically method. This study, 21 male Wistar albino rats were used. Rats were divided into three groups: control, 100 mg/kg ginger essential oil (G100), and 500 mg/kg ginger essential oil (G500). Hematoxylin-eosin staining method was used for histopathological evaluations. Immunohistochemically localization of catalase in kidney tissue was determined by streptavidin-biotin peroxidase method. As a result of histopathological evaluations, an increase in glomerulus diameter was observed in kidney tissues of G100 and G500 groups. In addition, vacuolar degeneration was observed in the proximal and distal tubule epithelial cells in the renal cortex of the G100 group. The immunoreactivity of catalase in the renal cortex region; In the control group, it is strong in the proximal tubules and very weak in the collecting ducts. In the G100 group, catalase immunoreactivity was weak in the proximal tubules and distal tubules and strong in the collecting ducts. In G500 group, weak catalase immunoreactivity was observed in only proximal tubules. Strong catalase immunoreactivity was detected in the proximal tubules of the kidney medulla regions of the rats in all groups. Furthermore, there was strong catalase immunoreactivity in collecting ducts in the medullary region of the G100 group. We think that ginger essential oil can be used in appropriate doses and durations to reduce kidney damage.